Explore the cell cycle with the Amoeba Sisters and an important example of when it is not controlled: cancer. We have an Unlectured resource for this topic: https://www.amoebasisters.com/unlectured Expand video details for table of contents. 👇 Video also mentions cell cycle checkpoints and cell cycle control. Table of Contents: 1:00 Cell Growth and Cell Reproduction 1:42 Cancer (explaining uncontrolled cell growth) 3:27 Cell Cycle 5:26 Cell Cycle Checkpoints 6:48 Cell Cycle Regulation 8:16 G0 Phase of Cell Cycle Vocabulary in this video includes the words apoptosis, G1, S, G2, mitosis, and cytokinesis. Positive regulator proteins such as cyclins and cyclin dependent kinases are briefly mentioned as well as a negative regulator protein p53. Positive and negative regulation reference regarding cyclin types and cyclin rise/fall areas [in humans]: OpenStax, Biology. OpenStax CNX. http://cnx.org/contents/[email protected] Are you interested in how blood supply to cancer cells may differ from blood supply to healthy cells? Learn more in this Further Reading: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661770/ Support us on Patreon! http://www.patreon.com/amoebasisters Our FREE resources: GIFs: http://www.amoebasisters.com/gifs.html Handouts: http://www.amoebasisters.com/handouts.html Comics: http://www.amoebasisters.com/parameciumparlorcomics Connect with us! Website: http://www.AmoebaSisters.com Twitter: http://www.twitter.com/AmoebaSisters Facebook: http://www.facebook.com/AmoebaSisters Tumblr: http://www.amoebasisters.tumblr.com Pinterest: http://www.pinterest.com/AmoebaSisters Instagram: https://www.instagram.com/amoebasistersofficial/ Visit our Redbubble store at http://www.amoebasisters.com/store.html The Amoeba Sisters videos demystify science with humor and relevance. The videos center on Pinky's certification and experience in teaching science at the high school level. Pinky's teacher certification is in grades 4-8 science and 8-12 composite science (encompassing biology, chemistry, and physics). Amoeba Sisters videos only cover concepts that Pinky is certified to teach, and they focus on her specialty: secondary life science. For more information about The Amoeba Sisters, visit: http://www.amoebasisters.com/about-us.html We cover the basics in biology concepts at the secondary level. If you are looking to discover more about biology and go into depth beyond these basics, our recommended reference is the FREE, peer reviewed, open source OpenStax biology textbook: https://openstax.org/details/books/biology We take pride in our AWESOME community, and we welcome feedback and discussion. However, please remember that this is an education channel. See YouTube's community guidelines https://www.youtube.com/yt/policyandsafety/communityguidelines.html and YouTube's policy center https://support.google.com/youtube/topic/2676378?hl=en&ref_topic=6151248. We also reserve the right to remove comments with vulgar language. Music is this video is listed free to use/no attribution required from the YouTube audio library https://www.youtube.com/audiolibrary/music?feature=blog We have YouTube's community contributed subtitles feature on to allow translations for different languages, and we are thankful for those that contribute different languages! YouTube automatically credits the different language contributors below (unless the contributor had opted out of being credited). We are not affiliated with any of the translated subtitle credits that YouTube may place below. If you have a concern about community contributed contributions, please contact us.
Views: 446020 Amoeba Sisters
How does cancer develop? Learn how cancer grows and about mutation of cancer cells with Cancer Research UK. Watch this video to find out how cancer develops or learn more on our website: http://www.cancerresearchuk.org/about-cancer/what-is-cancer/how-cancers-grow The video explains how cancer develops when DNA is damaged, allowing a cell to multiply out of control. This animation shows what happens to the normal controls in a cell when cancer starts.
Views: 64602 Cancer Research UK
This video has been redone: https://youtu.be/QVCjdNxJreE Music in this old video used with permission from Adrian Holovaty (http://www.youtube.com/c/adrianholovaty). Support us on Patreon! http://www.patreon.com/amoebasisters Our FREE resources: GIFs: http://www.amoebasisters.com/gifs.html Handouts: http://www.amoebasisters.com/handouts.html Comics: http://www.amoebasisters.com/parameciumparlorcomics Connect with us! Website: http://www.AmoebaSisters.com Twitter: http://www.twitter.com/AmoebaSisters Facebook: http://www.facebook.com/AmoebaSisters Tumblr: http://www.amoebasisters.tumblr.com Pinterest: http://www.pinterest.com/AmoebaSisters Instagram: https://www.instagram.com/amoebasistersofficial/ Visit our Redbubble store at http://www.amoebasisters.com/store.html The Amoeba Sisters videos demystify science with humor and relevance. The videos center on Pinky's certification and experience in teaching science at the high school level. Pinky's teacher certification is in grades 4-8 science and 8-12 composite science (encompassing biology, chemistry, and physics). Amoeba Sisters videos only cover concepts that Pinky is certified to teach, and they focus on her specialty: secondary life science. For more information about The Amoeba Sisters, visit: http://www.amoebasisters.com/about-us.html We cover the basics in biology concepts at the secondary level. If you are looking to discover more about biology and go into depth beyond these basics, our recommended reference is the FREE, peer reviewed, open source OpenStax biology textbook: https://openstax.org/details/books/biology We take pride in our AWESOME community, and we welcome feedback and discussion. However, please remember that this is an education channel. See YouTube's community guidelines https://www.youtube.com/yt/policyandsafety/communityguidelines.html and YouTube's policy center https://support.google.com/youtube/topic/2676378?hl=en&ref_topic=6151248. We also reserve the right to remove comments with vulgar language. We have YouTube's community contributed subtitles feature on to allow translations for different languages. YouTube automatically credits the different language contributors below (unless the contributor had opted out of being credited). We are thankful for those that contribute different languages. If you have a concern about community contributed contributions, please contact us.
Views: 870119 Amoeba Sisters
Zinc may help to prevent, treat esophageal cancer! Research led by the University of Texas at Arlington reveals how zinc can target esophageal cancer cells and halt their growth, thereby bringing us closer to new prevention and treatment strategies for the disease. Zinc is a mineral present in a variety of foods - including oysters, red meat, poultry, beans, nuts, and whole grains - and it is also available as a dietary supplement. Zinc is one of the body's essential nutrients. Not only is it important for fetal and childhood development and sense of taste and smell, but the mineral also aids cell functioning, wound healing, and helps our immune system to stave off infection. Previous studies have identified zinc deficiency in patients with esophageal csancer, indicating that the mineral may also help to protect against the disease. However, the molecular mechanisms underlying zinc's potential anti-cancer effects have been a mystery - until now. Zinc, calcium, and esophageal cancer Study leader Zui Pan, of the College of Nursing and Health Innovation at the University of Texas at Arlington, and colleagues found that zinc targets and blocks a specific calcium channel in esophageal cancer cells, preventing them from proliferating, or growing and dividing. Pan and colleagues recently reported their results in The FASEB Journal. For their study, the researchers assessed how human esophageal cancer cell lines and healthy human cells respond to zinc. They found that in esophageal cancer cells, the mineral inhibits a calcium channel called Orai1. This dampens excitable calcium signaling - a known contributor to cancer cell growth - and prevents cancer cell proliferation. Additionally, the team found that zinc did not target the calcium channel in healthy cell lines. "Our study," explains Pan, "for the first time to our knowledge, reveals that zinc impedes overactive calcium signals in cancer cells, which is absent in normal cells, and thus zinc selectively inhibits cancer cell growth." "It now appears that zinc and calcium can have a cross talk, meaning that they can be linked." A new treatment for esophageal cancer? According to the American Cancer Society, around 16,940 new cases of esophageal cancer will be diagnosed in the United States this year, and there will be around 15,690 deaths from the disease. Although esophageal cancer survival rates have improved recently, the prognosis remains poor when compared with many other cancers; only 20 percent of patients will survive for at least 5 years after being diagnosed with esophageal cancer. Such statistics emphasize the need for new therapies to prevent and treat esophageal cancer, and Pan and colleagues believe that their findings suggest that zinc supplementation could be a feasible option. In future studies, the team plans to find out more about the link between zinc and calcium signaling, and how zinc supplementation could be used to combat esophageal cancer. In the meantime, the researchers believe that their findings highlight the importance of including zinc as part of a healthful diet. The National Institutes of Health (NIH) recommend that men and women should aim to get around 11 milligrams and 8 milligrams of zinc, respectively, every day. Zinc oxide nanoparticles may help destroy difficult-to-treat triple-negative breast cancer tumors Breast tumors that are so-called triple-negative are largely resistant to existing cancer drugs, giving patients an especially poor prognosis. Researchers at King Abdullah University of Science and Technology (KAUST), Saudi Arabia, and collaborators are now exploring a potential therapeutic option for such tumors that is based on the tumor-specific effects of zinc oxide (ZnO) nanoparticles. Previous studies have shown that ZnO treatment can kill cancerous cells while leaving healthy cells intact. However, the mechanism is poorly defined; some data suggest that ZnO particles are ingested by and dissolve within tumor cells, while other findings suggest that cells absorb free zinc released when these particles dissolve in the acidic tumor environment. In a study led by Jasmeen Merzaban, KAUST assistant professor of bioscience, and Alexandra Porter from Imperial College London, Ph.D. students Basma Othman and Ayman Abuelela used microscopy to observe what happened when triple-negative breast tumor cells were treated with ZnO. For comparison, they used both untargeted conventional ZnO nanoparticles as well as targeted nanoparticles tagged with a peptide that specifically recognizes a protein found on the surface of cancer cells. The results unambiguously supported a model in which the nanoparticles are consumed by the cells before inducing cell death. "We were able to observe in real time the uptake of both classes of ZnO nanoparticles and confirm the subsequent rise in zinc ion concentrations within cells prior to their death," said Merzaban. The targeted nanoparticles proved substantially more effective
Views: 4899 Healthy Eating Tips
Dr. Jack West, medical oncologist/lung cancer specialist, describes special management considerations for indolent lung cancers that may not require treatment or are at risk for "over-treatment."
In this video, cancer researcher Ty Bollinger speaks with the founder of the Dr. Rath Research Institute, Dr. Matthias Rath himself and the director of research, Dr. Aleksandra Niedzwiecki about micronutrients. We'll discover how they work to halt cancer cell growth. The full interview with Drs. Niedzwiecki & Rath is part of the "The Truth About Cancer: A Global Quest" docu-series. If you would like to support our mission and own all episodes of our latest docu-series, A Global Quest, please follow this link: http://bit.ly/a-global-quest-silver --------------------------------------------------- Join TTAC's 1 MILLION+ FB fans: http://bit.ly/agq-fb-ttac Find us on INSTAGRAM: http://bit.ly/agq-ig-ttac Visit our website: http://bit.ly/agq-website-ttac -------------------------------------------------- About Dr. Rath -------------------------------------------------- Dr. Rath was born in Stuttgart, Germany, in 1955. After graduating from medical school he worked as a physician and researcher at the University Clinic of Hamburg, Germany and the German Heart Center in Berlin. His research focused on the causes of arteriosclerosis and cardiovascular disease. Today Dr. Rath heads a research and development institute in nutritional and Cellular Medicine, in which Dr. Niedzwiecki functions as the head of research. His institute is conducting basic research and clinical studies to scientifically document the health benefits of micronutrients in fighting a multitude of diseases. Dr. Rath is a member of the New York Academy of Sciences, the American Heart Association and other scientific organizations. His popular science books “Why Animals Don’t get Heart Attacks – but People Do” and “Cancer” have sold several million copies in ten languages. -------------------------------------------------- About The Truth About Cancer -------------------------------------------------- The Truth About Cancer’s mission is to inform, educate, and eradicate the pandemic of cancer in our modern world. Every single day, tens of thousands of people just like you are curing cancer (and/or preventing it) from destroying their bodies. ---------------------------------------------------------------------- Inside The Truth About Cancer Docu-Series --------------------------------------------------------------------- Doctors, researchers, experts, and survivors show you exactly how to prevent and treat cancer in our 3 original docu-series: "The Quest for the Cures”, “The Quest for the Cures Continues”, “The Truth About Cancer: A Global Quest”, and on our website: http://bit.ly/ttac-docu-series In our docu-series, you’ll travel with Ty Bollinger who lost both his mother and father to cancer (as well as 5 other family members). Ty travels the country and the globe and sits down with leading experts, doctors, researchers, and cancer conquerors to find out their proven methods for preventing and treating cancer. Please join our email list to be notified of all upcoming events (including free airings of our docu-series): http://bit.ly/join-ttac-mission Learn more about our latest docu-series “The Truth About Cancer: A Global Quest” here: http://bit.ly/agq-gold --------------------------------------- About Ty & Charlene Bollinger --------------------------------------- Ty & Charlene Bollinger are devoted Christians, health freedom advocates, health researchers, documentary film producers, and best-selling authors. After losing several family members to conventional cancer treatments, they set out to learn the truth about cancer and the cancer industry, working together tirelessly to help others to learn the truth that sets them free to live healthy, happy lives. Ty & Charlene's heartbreak and grief coupled with their firm belief that chemotherapy, radiation, and surgery were NOT the most effective treatments available for cancer patients, led them on a path of discovery. On their journey, they interviewed cutting-edge scientists, leading alternative doctors, and groundbreaking researchers to learn about hidden alternative cancer treatments. What they uncovered helped to create The Truth About Cancer and its three awe-inspiring docu-series: ”The Quest for the Cures”, “The Quest for the Cures Continues”, and “The Truth About Cancer: A Global Quest.” Ty & Charlene speak frequently at seminars, expos, conferences, and churches. Together, they host a bi-weekly internet news program: TTAC Global Health News: http://bit.ly/ghn-episodes Their message is clear: CANCER IS NOT A DEATH SENTENCE. THERE IS ALWAYS HOPE. --------------------------------------- Join Us Next Time --------------------------------------- If you enjoyed this clip, sign up to secure your free spot at the next airing of our latest docu-series, A Global Quest, here: http://bit.ly/a-global-quest-free
Views: 14187 The Truth About Cancer
Acetogenins have the potential to prevent cancer cells from producing energy (ATP molecules) that they use to feed the abnormal division and growth of cancer cells. , Graviola plant chemicals can attach to tumor cells and stop them from reproducing.Graviola also known to raise the natural immunity of the body that helps in eliminating cancer cells naturally. To Read more visit our website http://www.itsallaboutcancer.co.uk/
Views: 45 its all about cancer
Cancer is a class of diseases characterized by out-of-control cell growth. ... Cancer harms the body when altered cells divide uncontrollably to form lumps or masses of tissue called tumors. • a cancerous cell manages to move throughout the body using the blood or lymphatic systems, destroying healthy tissue in a process called invasion • that cell manages to divide and grow, making new blood vessels to feed itself in a process called angiogenesis. Key facts • Cancer is one of the leading causes of morbidity and mortality worldwide, • The number of new cases is expected to rise by about 70% over the next 2 decades.Every year, cancer claims the lives of more than half a million Americans. Cancer is the second leading cause of death in the United States, exceeded only by heart disease. One of every four deaths in the United States is due to cancer.Lung cancer is by far the most common cause of cancer death in the UK, accounting for more than a fifth (22%) of all cancer deaths in males and females combined (2014).[1-3] The next most common causes of cancer death in UK people are bowel (10%), breast (7%) and prostate (7%) cancers.Among all four of the most common cancers lung, colorectal, breast, and prostate death rates are dropping, the American Cancer Society (ACS) reports. But while better screening methods and treatments are saving lives, some forms of cancer remain terribly lethal. each year age-standardised net survival for patients diagnosed during 2010-2011 in England and Wales range from 98% for testicular cancer to just 1% for pancreatic cancer. Of the 21 most common cancers, 12 have ten-year survival of 50% or more, and four types – testicular cancer, malignant melanoma, prostate cancer What causes cancer? Cancer arises from the transformation of normal cells into tumor cells in a multistage process that generally progresses from a pre-cancerous lesion to a malignant tumor.• unhealthy diet with low fruit and vegetable intake • lack of physical activity • alcohol use • sexually transmitted HPV-infection https://www.youtube.com/watch?v=ZYACxd4zAlA • infection by hepatitis or other carcinogenic infections • ionizing and ultraviolet radiation • urban air pollution • indoor smoke from household use of solid fuels. https://www.youtube.com/watch?v=bwOC7rN94Hc • Individual types of cancer There are said to be over 200 different types of cancer. prevention strategies https://www.youtube.com/watch?v=xRJVp7v3IEg To prevent cancer, people may • increase avoidance of the risk factors listed above; • vaccinate against HPV and hepatitis B virus; https://www.youtube.com/watch?v=DPU_QROmgNo • control occupational hazards https://www.youtube.com/watch?v=bwOC7rN94Hc This video helps to know about cancer types causes facts about cancer and prevention strategies from cancer. https://www.youtube.com/watch?v=fhcrJPpQLPo For more update and understand about different diseases visit our channel awareness and precautions video, thank you
Views: 61 Awareness and precautions videos
Cell division is essential for healthy growth of an organism. Cancer happens when cells divide uncontrollably and produce a growing lump or tumor. Originally created for DNA Interactive ( http://www.dnai.org ) TRANSCRIPT: Cell division is essential for healthy growth of an organism and complex genetic mechanisms have evolved to switch cell division on and off at the proper time for normal development. Cancer happens when cells divide uncontrollably and produce a growing lump or tumor. Tumors give out chemical signals that prompt the growth of blood vessels to supply them with oxygen and food. A particularly dangerous aspect of cancer is metastasis. Here, small pieces of the tumor break off and travel through the bloodstream to invade other parts of the body.
Views: 35712 DNA Learning Center
Subscribe to Dr. Greger’s free nutrition newsletter and get the Evidence-Based Eating Guide: A Healthy Living Resource from Dr. Greger and NutritionFacts.org. Sign up at https://www.nutritionfacts.org/healthkit. DESCRIPTION: The ability of eleven common fruits to suppress cancer cell growth in vitro was compared. Which was most effective—apples, bananas, cranberries, grapefruits, grapes, lemons, oranges, peaches, pears, pineapples, or strawberries? This reminds me of my #1 Anticancer Vegetable (http://nutritionfacts.org/video/1-anticancer-vegetable/) video (along with it's "prequel," Veggies vs. Cancer http://nutritionfacts.org/video/veggies-vs-cancer/). Other videos in which I rank various foods include: · A Better Breakfast (http://nutritionfacts.org/video/a-better-breakfast/) · Anti Up on the Veggies (http://nutritionfacts.org/video/anti-up-on-the-veggies/) · Antioxidants in a Pinch (http://nutritionfacts.org/video/antioxidants-in-a-pinch/) · Best Berries (http://nutritionfacts.org/video/best-berries/) · Best Fruit Juice (http://nutritionfacts.org/video/best-fruit-juice/) · Better Than Goji Berries (http://nutritionfacts.org/video/better-than-goji-berries/) · Better Than Green Tea? (http://nutritionfacts.org/video/better-than-green-tea/) · Glycotoxins (http://nutritionfacts.org/video/glycotoxins/) · Green Tea vs. White (http://nutritionfacts.org/video/green-tea-vs-white/) · The Healthiest Sweetener (http://nutritionfacts.org/video/the-healthiest-sweetener/) · Vegetables Rate by Nitrate (http://nutritionfacts.org/video/vegetables-rate-by-nitrate/) How can you consume cranberries palatably? Check out my recipe for Pink Juice with Green Foam (http://nutritionfacts.org/video/pink-juice-with-green-foam/). More berried treasure in my next three videos: · Cranberries versus Cancer (http://nutritionfacts.org/video/cranberries-versus-cancer/) · Strawberries versus Esophageal Cancer (http://nutritionfacts.org/video/strawberries-versus-esophageal-cancer) · Black Raspberries versus Oral Cancer (http://nutritionfacts.org/videoblack-raspberries-versus-oral-cancer) Have a question for Dr. Greger about this video? Leave it in the comment section at http://nutritionfacts.org/video/which-fruit-fights-cancer-better/ and he'll try to answer it! http://www.NutritionFacts.org • Subscribe: http://www.NutritionFacts.org/subscribe • Donate: http://www.NutritionFacts.org/donate • HOW NOT TO DIE: http://nutritionfacts.org/book • Facebook: http://www.facebook.com/NutritionFacts.org • Twitter: http://www.twitter.com/nutrition_facts • Instagram: http://instagram.com/nutrition_facts_org/ • Google+: https://plus.google.com/+NutritionfactsOrgMD • Podcast: http://nutritionfacts.org/audio/
Views: 304322 NutritionFacts.org
How does cancer form? Why is it so common? What can you do to minimise your risk of getting cancer. The answers and more in this video! Cancer is an uncontrolled growth of cells that can occur in anybody at any time, and it can make you very sick. It can even kill you...but don't worry, more people beat cancer than die from it, and as medicine advances, so to do our treatments for cancer. Normally, cells grow and divide to maintain our bodies and keep us alive. Every time a cell divides, it needs to make a copy of our DNA, all 3'200'000'000 base pairs of it, so SOMETIMES there is a mistake! Approximately 1 in every one million base pair copies is a mistake, also known as a mutation. Most mutations are harmless, but sometimes they can impact a specific gene involved in the cell cycle, which can lead to a hallmark of cancer! Hallmark 1: Uncontrolled growth and division of cells. Cells normally grow and divide slowly, but if a cell mutates to increase its rate of replication, this can turn it into a cancer cell. Hallmark 2: No Apoptosis. If a cell becomes mutated seriously, normally it would commit cell suicide, apoptosis. However, if the gene for apoptosis is mutated, the cell could refuse to die and continue growing and mutating. Hallmark 3: Angiogenesis. Cancer cells cannot grow and divide very much without a blood supply for nutrition, but if the gene the promotes blood vessel growth (angiogenesis) becomes mutated, it can cause blood vessels to move toward the cancer cells and provide them with nutrition to continue growth. Hallmark 4: Metastasis. Cancer cells cannot do too much damage when they are localised to one place in the body, but if the cancer cells mutate to release from their location and move and spread through the bloodstream (metastasis), this is a very serious hallmark of cancer. These mutations are rare...but because your cells are dividing and mutating constantly, it is likely that one of your cells at some point in your life could develop into a cancerous tumour. To reduce your risk of developing a cancer, avoid carcinogens. Carcinogens are substances that promote cancer. Things like radiation, plutonium, asbestos, lead, X-rays, exhaust fumes, pollution, sawdust, chimney sweeps, coal, the sun, hepatitis, epstein bar virus, Human Immunodeficiency virus and anybody who has these viruses, cigarettes, anybody who smokes, alcohol, oestrogen, paint, salted fish (Chinese style), very hot beverages, burned meat, burned toast, burned anything, and of course…bacon. Avoid these things to reduce your risk of suffering from cancer. Next weeks video will be all about how we treat cancer and the future of medicine for this disease. For more information on cancer and carcinogens, use the links below. WHO Cancer Facts https://www.who.int/en/news-room/fact-sheets/detail/cancer Cancer Treatments https://www.cancer.gov/about-cancer/treatment/types Mutation Rate Article https://www.theatlantic.com/science/archive/2018/05/your-body-acquires-trillions-of-new-mutations-every-day/559472/ Cancer Risks https://www.cancer.org/cancer/cancer-basics/lifetime-probability-of-developing-or-dying-from-cancer.html Why cancer makes you feel sick https://www.cancerresearchuk.org/about-cancer/coping/physically/sickness/causes/cancer Carcinogens https://www.cancer.org/cancer/cancer-causes/general-info/known-and-probable-human-carcinogens.html http://www.thetravellingscientist.com.au https://www.patreon.com/thetravellingscientist Use the links below to follow The Travelling Scientist YouTube: https://www.youtube.com/channel/UC0OPSqjSuqsDPhZFokbVxZg?view_as=subscriber Facebook: https://www.facebook.com/travellingscientist/ Instagram: https://www.instagram.com/travellingscience/ Twitter: https://twitter.com/jctravelscience
Views: 84 The Travelling Scientist
In this short tutorial, i have described an interesting Hallmark of Cancer- WARBURG EFFECT. You will learn the What, Why and How of This Effect. ****Follow me***** http://ilovepathology.com/ Twitter : https://twitter.com/VijayPatho https://twitter.com/ilovepathology2 Facebook: https://www.facebook.com/ilovepathology/ Warburg effect in Cancer The major metabolic shift Reprogramming Energy Metabolism in the presence of adequate ocygen ATP is generated by Oxidative Phosphoryation As Oxygen Decreases Shift from Oxidative phosphorylation to Glycolysis- Anaerobic glycolysis PASTEUR EFFECT Otto Heinrich Warburg , German Physiologist Observed that cancer cells had increased rates of glycolysis Despite the availability of adequate oxygen levels- WARBURG EFFECT The puzzling questions Is this phenomenon Cancer specific? No! This is evident in rapidly growing normal tissues too as in embryonic tissue It is a property of growing cells but got “stuck” in cancer cells!! Why do cancer cells activate glycolysis despite the presence of oxygen? Assures ATP synthesis when tumor outgrows its oxygen supply The metabolic intermediates of AEROBIC GLYCOLYSIS provides raw material for the synthesis of cellular components in these rapidly dividing tumor cells! And also favor tumor growth Release of acid lowers extracellular pH which favors tumor invasion and suppresses immune effectors How do they manage to activate glycolysis despite the presence of oxygen? Induction of glycolytic enzymes BY overexpression of HIF 1 Induction of Pyruvate dehydrogenase kinase Down regulation of mitochondrial enzymes and decrease in the number of mitochondria Mitochondrial defects due to mutations in mitochondrial DNA leading to malfunction of oxidative phosphorylation Significance of understanding Warburg effect Diagnostic This property of “glucose hunger” is used in PET scanning of solid tumors 18F-flourodeoxyglucose, a nonmetabolizable glucose derivative of glucose is used where this is preferentially taken by tumor cells/rapidly dividing cells Therapeutic Numerous Glycolytic inhibitors have been developed which can be potential anticancer drugs Viewpoint! Warburg effect is a growth promoting metabolic alteration in cancer cells One of the Hallmarks of Cancer! lots of explanations are given for this effect. However the exact cause and its value,.. As of now still remains elusive!
Views: 31666 ilovepathology
https://www.naturalnews.com/2017-12-03-cancer-hates-oxygen-research-shows-that-a-shortage-of-oxygen-in-the-cells-is-how-many-cancer-tumors-grow.html Sources include: Nieuws.Kuleuven.be ScienceDaily.com Cancer.org Cancer hates oxygen: Research shows that a shortage of oxygen in the cells is how many cancer tumors grow Normalizing the oxygen supply in tumors may inhibit the progression of cancer, according to a study published in the journal Nature. The scientific community has well established the mechanism behind cancer onset. Experts note that the disease stems from a single cell’s DNA mutation, either by chance or due to carcinogenic factors, which is then followed by the rapid expansion of the abnormal cell. According to scientists, these harmful genetic mutations affect the functions of otherwise normal cells. However, the experts say that these mutations are necessary for the growth and survival of cancer cells. Health experts also explain that aside from these genetic changes, tumor cells also exhibit epigenetic changes. These changes have something to do with how genes are expressed. As part of the new study, the researchers have examined more than 3,000 patient tumors to see how hypermethylation contributes to cancer onset. The scientists explain that hypermethylation is a process where high amounts of methyl groups are added to the cell’s DNA. The researchers stress that hypermethylation dampens the expression of tumor suppressing genes as a result, which then speeds up abnormal cellular behavior and excessive tumor growth. “Our study shows that hypermethylation is caused by oxygen shortage or hypoxia. In fact, oxygen shortage explains up to half of the hypermethylation in tumors. While we dedicated much of our efforts to breast tumors, we also demonstrated that this mechanism has a similarly broad impact in bladder, colorectal, head and neck, kidney, lung, and uterine tumors,” researcher Professor Diether Lambrechts reports in Ku Leuven News online. Starving tumor cells of oxygen may mitigate cancer onset The researchers then used animal models to see whether targeting tumor oxygen supply may impact cancer progression. Data from the clinical trial confirm that normalizing the blood supply in tumors may effectively mitigate epigenetic changes from occurring. The findings show potential in cancer management, the researchers say. The results may also lead to the development of new anti-cancer drugs that target blood vessels or the epigenetic abnormalities, the experts add. “Our new insights can have a potentially huge impact on cancer management. First of all, we could use epigenetic aberrations to monitor the oxygen supply to a tumor, allowing us to better predict tumor behavior and make more informed treatment decisions. Secondly, it sheds new light on existing blood vessel targeting therapies. They don’t only help deliver chemotherapy to the tumor, but also inhibit new epigenetic aberrations. This could in turn help make relapses less aggressive, and thus prove to be therapeutically beneficial,” researcher Dr. Bernard Thienpont tells Science Daily online. The researchers have already began testing whether tumor DNA analysis can be used to predict tumor oxygenation. The experts have also commenced research about potential therapies that help normalize blood vessels. “We want to know whether it’s not just possible to inhibit, but maybe even to reverse some of these epigenetic aberrations. Following through on these and other new research avenues gives us great faith in the future of cancer research,” Professor Lambrechts adds. Fast facts about U.S. cancer rates The American Cancer Society (ACS) estimates that: A total of 1,688,780 new cancer cases will be diagnosed in the U.S. in 2017 alone. A total of 600,920 cancer deaths will occur across the country. About 13 percent of diagnosed cases in adults ages 20 and older will be rare forms of cancer. Cancer incidence rate is 20 percent higher in men than in women. Cancer death rate is 40 percent higher in men than in women. Cancer death rate is 15 percent higher in blacks than in whites. Follow more news on anti-cancer therapies and science at AntiCancer.news.
Views: 1777 Natural Remedies
Cancer and the cell cycle. Like ultraviolet light) all cause mutations in genes, but normal errors that emulate the body's natural process order to stop growth of cancer cells. Rather than responding appropriately to the signals that control normal cell behavior, cancer cells grow and divide in an uncontrolled manner, invading tissues organs eventually spreading throughout body. The development and causes of cancer. In cancer cells, the genes that control growth are abnormal, causing uncontrolled of cells 9 feb 2015 is a genetic disease is, it caused by changes to tumor suppressor also involved in controlling cell and division. Cancer cells may make cancer also ignore signals that should cause them to stop dividing cancer, group of more than 100 distinct diseases characterized by the uncontrolled growth abnormal in body. Cancer facts, causes, symptoms and research the development causes of cancer cell ncbi bookshelf. What is cancer? American cancer society. Most cancers are caused by a change in or damage to genes 24 nov 2015 learn about the causes of cancer and different types, plus cells can experience uncontrolled growth if there mutations dna, 8 dec keep on growing making new. An example of 20 nov 2016 and the quote is this,' cancer a disease caused by uncontrolled growth single cell. There are many different types of cancer, they all start because uncontrolled, abnormal growth cells. Cancer facts, causes, symptoms and research. Rather than responding appropriately to the signals that control normal cell behavior, cancer cells grow and divide in an uncontrolled manner, invading tissues organs eventually spreading throughout body conclusion. This growth is unleashed by mutations changes occasionally, cells begin to grow in an uncontrolled fashion, causing many problems for the body. View through an endoscope of a polyp, benign precancerous growth projecting from the inner lining. Cancer cell development canadian cancer society. Cells acquire mutations in more genes, causing uncontrolled growth cancer cells are different from normal. Cancer is unchecked cell growth. For the continuous, uncontrolled growth seen in cancer genetic faults within cells to cause cancerous mutations can experience if there are damage or mutation dnaCancer facts, causes, symptoms and research. Limit the damage to normal cells and accompanying side effects caused by regulatory process malfunctions, resulting in uncontrolled cell proliferation that is, cancer develops from changes cause acquire abnormal mutated growth. Gov books nbk9963 the development and causes of cancer. As a mass of cancerous cells grows, it can develop into tumor normally, the orders for cell growth are clear and our obey. Mutations in genes can cause cancer by accelerating cell division rates or inhibiting normal controls on the system, such as cycle arrest programmed death. What is cancer? Usc department of surgery. Tumor formation uncontrolled cell division johns hopkins genetics of cancer lsu
Views: 115 Don't Question Me
New Delhi, Apr 05 (ANI): In new research, scientists have come up with a new formula that predicts tumour growth rate more accurately, a crucial statistic used to schedule screenings and set dosing regimens in cancer treatment. The research, published in the AAPS Journal, was led by Dhaval Shah, PhD, associate professor in the UB School of Pharmacy and Pharmaceutical Sciences. The mathematical method successfully estimated the doubling time, the amount of time for a tumour to double in size, for 12 types of cancer, ranging from breast and prostate cancers to melanoma."This novel method allows clinicians and drug development scientists to use routinely-generated clinical data to infer doubling times of solid tumours. This parameter can be used to design individualised dosing regimens and develop reliable models for anticancer therapeutics," said Shah. Tumour doubling time can significantly affect the outcome of anticancer therapy, but the rate is challenging to determine. The UB researchers instead base their method on data extracted from progression-free survival plots - the length of time during and after treatment that cancer does not grow or spread. Progression-free survival plots explained Shah, inherently contain information that could help identify tumour growth rates. The investigators examined data from 47 clinical trials that reported plots for any of 12 cancer types: melanoma; pancreatic, lung, prostate, gastric, colorectal and three forms of breast cancer; hepatocellular (liver) and renal cell (kidney) carcinoma; and glioblastoma multiforme (brain). The cancer growth rates predicted by the researchers using progression-free survival plots were within close range to the reported actual tumour doubling times. ---------------------------------------------------------------------------------------------- ☛ Subscribe to our Youtube Channel - https://goo.gl/k1Aee1 ☛ Visit our Official website: https://www.aninews.in/ Enjoy and stay connected with us!! ☛ Like us: https://www.facebook.com/ANINEWS.IN ☛Follow us : https://twitter.com/ANI ☛ Circle us : https://goo.gl/QN5kXy ☛ Feedback to Shrawan K Poddar : [email protected]
Views: 30 ANI News Official
Researchers studying growth rates of single cells researchers say that mammalian cells divide not when they reach a critical size, but when their growth rate hits a specific threshold. Source: MIT Read more: http://www.laboratoryequipment.com/videos/2012/08/researchers-find-link-between-cell-division-growth-rate
Views: 75 Laboratory Equipment
A cell is the functional basic unit of life, often called the building block of life. Humans have about 100 trillion cells. You body is constantly producing new cells. In this program, we will discuss how cells divide, how chemotherapy affects cells that are dividing, and how chemotherapy affects cancer cells. When a normal cell divides, it goes through a series of steps, including a duplication of its DNA, which contains the genetic instructions used in the development and functioning of living organisms. The end result of the cell division is the formation of two identical daughter cells. Let's begin to explore how this process happens. The cell goes through many distinct steps as it divides. After a cell's initial formation, it goes into an inactive resting phase called G zero. The cell then grows larger in size and makes proteins. These are important for the next step. This phase is called G1. The cell creates two copies of its DNA in preparation for dividing. This is called the S phase. After a second growth phase called G2, the cell continues to grow and make more proteins for the final stage. The cell finally splits into two cells and the two copies of DNA are distributed equally between the two daughter cells. This is called the M phase or mitosis. This completes the process of cell division. In normal cells, there are checkpoints at every stage of this process to make sure that cells grow and divide in a regulated way. In cancer cells, these checkpoints are broken, and cancer cells grow out of control. Chemotherapy drugs act in many different ways to disrupt cell division. Some chemotherapy drugs can act on resting cells, as well as actively dividing cells. Other chemo drugs can act on cells only during specific stages of the cell cycle. For example, some chemo drugs bind to DNA exactly when the cell is making a copy of its DNA. By preventing the cell from making a second copy of the DNA, the drugs stop the cells from dividing. Other chemo drugs prevent cells from splitting into two daughter cells. They prevent the DNA from being equally divided between the two cells, Thereby preventing cell division. Cancers are formed when abnormal cells divide rapidly without any control. Because chemotherapy drugs target different steps during the process of cell division,... They are good at killing cells that are dividing rapidly, like cancer cells. Chemotherapy drugs can also damage normal cells that are dividing rapidly and this can cause side effects like hair loss.
Views: 346328 chemotherapy
Medication alone is not enough to kill off and fight Cancer Cell growth. In this video Dr Greger uses Scientific evidence and studies to prove a Vegan Diet is 8 TIMES STRONGER AT FIGHTING CANCER!!! Than your standard Western diet. Please SHARE this video with anyone you know who may be battling with cancer and making the mistake of fuelling it by eating Meat, Eggs, Dairy and fish. SUBSCRIBE to The Vegan Runner for Daily uploads on Veganism and Running fitness!!!
Views: 16237 The Runner
Behold The Future...Scientists at the Mayo Clinic in Florida in the Department for Cancer Biology have successfully reprogrammed lung, breast, and bladder cancer cells back into normal, healthy cells by bringing back the function that prevents them from multiplying in excess. While the tests have only been conducted on human cells in the lab (rather than human trial), their work has tremendous implications for the future of cancer treatment. Researchers are hopeful that the technique could one day be used to target tumours, so that the cancer will be “switched off” without the need for chemotherapy, surgery, or other drugs. This important study solves a long-standing biological mystery, but we mustn’t get ahead of ourselves. There’s a long way to go before we know whether these findings, in cells grown in a laboratory, will help treat people with cancer. But it’s a significant step forward in understanding how certain cells in our body know when to grow, and when to stop. Understanding these key concepts is crucial to help continue the encouraging progress against cancer we’ve seen in recent years. – Henry Scowcroft, Cancer Research UK’s senior science information manager When the US researchers added molecules called microRNAs, it stopped the cancer in its tracks. According to Professor Panos Anastasiadis, Chair of the Department for Cancer Biology on Mayo Clinic’s Florida Campus: We can effectively reprogram them (cancer cells) to become and behave as normal. So we can take very aggressive tumour cells that are growing and migrating, replenish them with the microRNAs that are deregulated, and that effectively turn them into normal cells. It’s quite amazing how many discoveries have been made in the last decade alone which show promising results for cancer eradication. Cannabis is a great example. For years, many studies have shown how multiple properties within cannabis completely kill cancerous tumours, yet no clinical trials have been conducted on humans. Despite this fact, a number of people have taken matters into their own hands and have had a tremendous amount of success treating their cancer in this way – Mykayla Comstock is a great example. You can find links to studies that are embedded in various articles that we’ve written on this subject by clicking here. Here is an article we wrote regarding a little known Chinese herb that can kill 12,000 cancer cells for every healthy cell, and a simple Google search would show you just how many vegetables are capable of fighting cancer, broccoli being one great example. The point I am trying to make is that there are a number of ways you can keep healthy. With cancer rates on the rise, at a staggering (approximately) one in two chance of developing the disease in your lifetime, we need to start shifting the conversation and talking about cancer prevention rather than just cancer treatment. And that all starts with looking at our toxic environment. A number of links have been made between cancer and the pesticides that we spray all over our food and the environment. Not to mention the heavy metals in our cosmetics, the Genetically Modified Food, processed food, everyday household products, ingredients within toothpastes and deodorants, and a thousand other consumer goods – we are surrounded by carcinogens on a daily basis. It’s clear that we need to find a better way to do things here. http://www.collective-evolution.com/2015/09/14/big-news-cancer-cells-were-recently-programmed-back-to-normal-healthy-ones/?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+Collective-evolution+%28Collective+Evolution%29 --------------------------------------------------------------------------- Mayo Clinic Researchers Find New Code That Makes Reprogramming of Cancer Cells Possible...Cancer researchers dream of the day they can force tumor cells to morph back to the normal cells they once were. Now, researchers on Mayo Clinic’s Florida campus have discovered a way to potentially reprogram cancer cells back to normalcy. Panos Anastasiadis, Ph.D., chair of the Department of Cancer Biology on Mayo Clinic’s Florida campus comments on the findings which are published in Nature Cell Biology. https://www.youtube.com/watch?t=10&v=yGYTLOGZ40U
Views: 1206 UPHIGH Productions
By watching what two known cancer-promoting proteins did to blood-forming stem cells, Duke researchers believe they have seen one protein speeding up cell division, and another controlling the maturational state of cells that are produced -- both hallmarks of cancerous growth.
Views: 710 Duke Health
► Could Bitter Melon be the Key to an Alternative Cancer Treatment Unless you are an enthusiast for Asian cookery, you may not be aware of the bitter melon. This vegetable is frequently used in Asian cuisine, but recent research from the Saint Louis University has suggested that, it could be the key to an alternative form of cancer treatment. The research documents the use of bitter melon extract as a treatment in cancer cells in mice. The researchers have noticed an effect of slowed growth in neck and head cancer cells. The team have stated that, it is challenging to measure the possible “impact” of using a bitter melon treatment in reducing cell growth rates. However, according to Ratna Ray Ph. D the research shows, promise in combination with existing treatments to improve “the efficacy of the overall cancer treatment”. Neck and head cancer cases, which account for approximately six percent of all reported cancer cases, generally start in the sinuses, throat, mouth or voice box. However, they are generally a very aggressive form of cancer, which will often spread in the head and neck region. The bitter melon or Momordica charantia is commonly used in alternative or folk medicine, because of the reputed hypolipidemic and hypoglycemic effects. The initial research from the Saint Louis team has shown encouraging results for the treatment, of a number of different forms of cancer including breast cancer. The team noted the “significantly decreased proliferation” caused by the bitter melon which could induce the death of cancer cells. This preliminary research has suggested hope for an alternative treatment in slowing down the growth, and inducing cancer cell death. Further research is planned by Ray and her team to document the effects on other types of cancer cells, and investigate the “chemo-preventive efficacy” in an oral administration of the extract. While this may not be an immediate form of treatment, it does show great promise and in the future could be the key to effective treatment programs. ★ Please leave a like if you enjoyed and tell me what you think in the comments! ★ Don't forget to subscribe my channel to help us reach to 100.000 Subscribers : https://goo.gl/29sHF2 --------------------------------------------------------------------------------- ★ VIEW MORE: ➞ Tips & Tricks: https://goo.gl/UdhRLs ➞ Natural Remedies: https://goo.gl/djrthu ➞ Diet & Weight Loss: https://goo.gl/7sEJCX ➞ Beauty Tips: https://goo.gl/E3nsCd ➞ Healthy Drinks: https://goo.gl/BSGh2E --------------------------------------------------------------------------------- ★ Like our facebook page: https://goo.gl/tVNSqu --------------------------------------------------------------------------------- ★ Videos can use content-based copyright law contains reasonable use Fair Use (https://www.youtube.com/yt/copyright/)
Views: 334 Good Health and Nutrition
This video and other related images/videos (in HD) are available for instant download licensing here : https://www.alilamedicalmedia.com/-/galleries/images-videos-by-medical-specialties/medical-genetics ©Alila Medical Media. All rights reserved. Support us on Patreon and get FREE downloads and other great rewards: patreon.com/AlilaMedicalMedia All images/videos by Alila Medical Media are for information purposes ONLY and are NOT intended to replace professional medical advice, diagnosis or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition. Perfect for patient education. The number of cells in a tissue is determined by the balance between cell division and cell death. Uncontrollable cell division leads to formation of abnormal growths called tumors. Tumors can be benign or malignant. Benign tumors are slow-growing and constrained by surrounding connective tissue so they do not spread to other organs. They can still be harmful or even kill by pressing on nearby nerves, brain tissue or blood vessels. Examples of benign tumor include pituitary tumors which may press on optic nerves and cause loss of vision. Cancers are malignant tumors - tumors that can spread beyond of the limit of original organ where it comes from and to other organs of the body. How cancer starts Cancer starts from damage in the DNA of a cell. This DNA damage is called mutation. Mutations happen when the cell duplicates its DNA prior to cell division and makes mistakes. These damages are usually detected and repaired before the cell can divide but sometimes, some of them may be ignored and transferred to daughter cells. If the mutation is located in one of many genes that control the cell cycle, it may affect the regulation of cell cycle in the cell carrying it, and make the cell divide faster than it supposed to. Usually, one mutation is not enough to cause cancer, but as it makes the cell cycle control less reliable, many more DNA damages/mutations would go unnoticed. Cancer is usually the result of accumulation of many mutations of genes involved in cell cycle control and DNA repair. This commonly happens over a long period of time, over many rounds of cell divisions, and this explains why cancers are more common in older people. Some people are said to be predisposed to cancer. This is because they are born with a mutation that makes them more likely to develop a certain type of cancer. This mutation alone is not enough to cause cancer but it starts the process of making cells cancerous. The person carrying it is one step further down the road towards developing a cancer than others who do not have the mutation. How cancer spreads Cancer cells do not stick together like normal cells, they move and invade nearby tissues, organs, this is local spread. They may also spread to further away organs by means of blood and lymph circulation, this is systemic spread. Metastasis is the spreading of cancers to non-adjacent organs. Cancer cells from the original tumor, or primary cancer, can break out and maybe taken up by a blood or a lymph vessel for a ride throughout the body. They can then squeeze out from the vessels into other tissues and start a new tumor growth in the new location which will become secondary cancer. Where do cancers usually spread and why? While travelling in the bloodstream, cancer cell usually stops at the first place where the vessel getting so narrow that it gets stuck. As blood flow from most organs goes to the capillaries of the lungs, this is where cancers spread the most. Lungs are indeed the most common site of secondary cancers. Likewise, while travelling in the lymphatic system, cancer cells commonly get stuck in nearest lymph nodes, where the vessels get narrower. This is the reason why surgeons usually remove nearby lymph nodes when removing tumors.
Views: 191498 Alila Medical Media
It's a longstanding question in biology: How do cells know when to progress through the cell cycle? In simple organisms such as yeast, cells divide once they reach a specific size. However, determining if this holds true for mammalian cells has been difficult, in part because there has been no good way to measure mammalian cell growth over time. Now, a team of MIT and Harvard Medical School (HMS) researchers has precisely measured the growth rates of single cells, allowing them to answer that fundamental question. In the Aug. 5 online edition of Nature Methods, the researchers report that mammalian cells divide not when they reach a critical size, but when their growth rate hits a specific threshold.
Views: 3778 Massachusetts Institute of Technology (MIT)
Researchers discover How Zinc halts the growth of cancer paving the way for possible new treatments using Zinc supplementation. Citation: Selective inhibitory effects of zinc on cell proliferation in esophageal squamous cell carcinoma through Orai1. The FASEB Journal, 2017; fj.201700227RRR DOI: 10.1096/fj.201700227RRR
Views: 531 VHFILM
CANCER BREAKTHROUGH: Take This TRACE MINERAL And You Will Halt The Growth Of Deadly Cancer Cells! Click here to get natural products from our shop: https://www.amazon.com/shop/ajaancestralhealing Click here for more natural products from hundreds of our retail partners: http://obsessedwith.it/ajaancestr/ Visit our website for even more natural cures and health tips: http://ajaancestralhealing.blogspot.com/ Click here to get T-Shirts from our shop: https://shop.spreadshirt.com/ajaancestralhealing/ Click here to see the equipment used in this video production: https://kit.com/ajaancestralhealing Click this link to SUBSCRIBE for more informational videos: https://goo.gl/iJWJ6u Support this channel by donating: http://bit.ly/2v3AYbF Watch our most recent upload: https://goo.gl/6PhL40 Watch our most popular upload: https://goo.gl/Va1CLA _____________________________________________________________ PLAYLISTS: SUPERFOODS: http://bit.ly/2CrZpyv Lose Weight With Home Remedies: http://bit.ly/2spgkka How To Clean Out The Body And Lose Weight: http://bit.ly/2Gmdrnp Natural Teeth Remedies: http://bit.ly/2GphIGX Natural Remedies to Fight Cancer: http://bit.ly/2Fci83K Remedies for Cold, Flu, Mucus, Phlegm: http://bit.ly/2sBCbpU How To Prevent Diseases From Spreading: http://bit.ly/2o96r6E Natural Remedies to Clean the Colon: http://bit.ly/2Fdthla Cure Impotence or Erectile Dysfunction: http://bit.ly/2FaLuQi Improve Your Sex Life Naturally: http://bit.ly/2C6GtcA Natural Remedies for Breast Issues: http://bit.ly/2Exd5y1 Natural Treatments For Aging: http://bit.ly/2FbQd4a Naturally Cure Diabetes: http://bit.ly/2BxUjDY Beauty Tips: http://bit.ly/2EOhJqM _____________________________________________________________ SOCIAL MEDIA LINKS: PayPal: https://www.paypal.me/AJAAncestralHealing Patreon: https://www.patreon.com/ajaancestralhealing Facebook: https://www.facebook.com/ajaancestralhealing/ Twitter: https://twitter.com/ajaancestorheal Pinterest: https://www.pinterest.com/ajaancestralhealing/ Instagram: https://www.instagram.com/ajaancestralhealing/ Tumblr: https://ajaancestralhealing.tumblr.com/ Reddit: https://www.reddit.com/user/ajaancestralhealing/ Google+: https://plus.google.com/+AJAAncestralHealing Music: https://soundcloud.com/templeoftikal _____________________________________________________________ IN THIS VIDEO: Cancer of the esophagus is a deadly condition, with symptoms including indigestion and difficulty swallowing. Esophageal cancer is the sixth leading cause of human cancer deaths around the world, according to the National Cancer Institute. The institute estimates that there were almost 16,000 esophageal cancer deaths in the United States in 2016. The average five-year survival rate is less than 20 percent.... SCIENTIFIC STUDIES: https://www.ncbi.nlm.nih.gov/pubmed/20155630 https://www.ncbi.nlm.nih.gov/pubmed/17344507 https://www.ncbi.nlm.nih.gov/pubmed/10801966 https://www.ncbi.nlm.nih.gov/pubmed/25263460 https://www.ncbi.nlm.nih.gov/pubmed/10801966 https://www.ncbi.nlm.nih.gov/pubmed/23775705 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693724/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102454/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872358/ http://www.fasebj.org/content/early/2017/09/14/fj.201700227RRR http://www.uta.edu/news/releases/2017/09/zui-pan-zinc-cancer-research.php _____________________________________________________________ DISCLAIMER: The materials and the information contained on AJA Ancestral Healing channel are provided for general and educational purposes only and do not constitute any legal, medical or other professional advice on any subject matter. These statements have not been evaluated by the FDA and are not intended to diagnose, treat or cure any disease. Always seek the advice of your physician or other qualified health provider prior to starting any new diet or treatment and with any questions you may have regarding a medical condition. If you have or suspect that you have a medical problem, promptly contact your health care provider. _____________________________________________________________ ABOUT US: AJA Ancestral Healing provides relevant information and tips on the usage of natural remedies to prevent, treat and heal ailments. The channel is named after AJA, the Orisha patron of the forest and all animals within it. AJA holds the secrets of botany, and is a master of potions and healing herbs. She passed this skill to the Yoruban people, who practice her craft to this very day. _____________________________________________________________ DON'T FORGET TO SHARE, LIKE, COMMENT, AND SUBSCRIBE. _____________________________________________________________
Views: 2083 AJA Ancestral Healing
This movie is a 3D multi-cell simulation of a generic vascular tumor growth which can be easily extended and adapted to describe more specific vascular tumor types and host tissues. Initially, the tumor grows exponentially. When oxygen level drops below a threshold, the normal tumor cells become hypoxic and start secreting a long-diffusing proangiogenic factor. At this stage, the tumor reaches a maximum diameter of about 300 micrometers. The activated neovascular cells in the pre-existing vasculature respond to the pro-angiogenic factors both by chemotaxing towards higher concentrations of the proangiogenic field and by forming new blood vessels via angiogenesis. The tumor-induced neovascular network enhances oxygen supply and tumor growth. Total movie time = 75 days. Time interval between frames = 6 hours. The camera rotates at a rate of 0.1 degree per frame. Cell types: Green: normal; yellow: hypoxic; blue: necrotic; red: vascular; purple: neovascular. Axes are labeled in micrometer. more info: Abbas Shirinifard, J. Scott Gens, Benjamin L. Zaitlen, Nikodem J. Popławski, Maciej Swat, James A. Glazier (2009) 3D Multi-Cell Simulation of Tumor Growth and Angiogenesis. PLoS ONE 4(10): e7190. doi:10.1371/journal.pone.0007190
Views: 1529 Abbas Shirinifard
In this video Paul Andersen answers the very simple question: What is cancer? He explains how damage to the DNA can create uncontrolled cell growth. He explains how malignant tumors can spread the disease throughout the body and gives possible treatments. Do you speak another language? Help me translate my videos: http://www.bozemanscience.com/translations/ Music Attribution Title: String Theory Artist: Herman Jolly http://sunsetvalley.bandcamp.com/track/string-theory All of the images are licensed under creative commons and public domain licensing: Asd.and.Rizzo. English: Cancer Cells Photographed by Camera Attached to Microscope in Time-Lapse Manner., July 23, 2008. Own work. http://commons.wikimedia.org/wiki/File:TimeLapseMicroscopyCancerCells.gif. BruceBlaus. English: Epidermis. See a Full Animation of This Medical Topic., January 29, 2014. Own work. http://commons.wikimedia.org/wiki/File:Blausen_0353_Epidermis.png. "File:Thorax Pa Peripheres Bronchialcarcinom Li OF Markiert.jpg." Wikipedia, the Free Encyclopedia. Accessed March 23, 2014. http://en.wikipedia.org/wiki/File:Thorax_pa_peripheres_Bronchialcarcinom_li_OF_markiert.jpg. Häggström, Mikael. English: Image for Use in the Human Body Diagrams Project. To Discuss Image, Please See Talk:Human Body Diagrams, May 25, 2011. All used images are in public domain. http://commons.wikimedia.org/wiki/File:Man_shadow_with_organs.png. Meyer, D. Glivec (Gleevec) Film Tablet Made by Novartis., July 2, 2006. Photo made by myself. http://commons.wikimedia.org/wiki/File:Glivec_tablet.jpg. Sponk, Difference_DNA_RNA-EN svg: *Difference_DNA_RNA-DE svg: English: DNA in Eukaryote Cell, August 5, 2012. This file was derived from: Difference_DNA_RNA-EN.svg Chromosome.svg Animal_cell_structure_en.svg. http://commons.wikimedia.org/wiki/File:Eukaryote_DNA.svg.
Views: 139191 Bozeman Science
A new study led by Salk Institute scientists and published in Cell suggests that high-fat diets fuel colorectal cancer growth by triggering a hormonal signal that lets potentially cancerous cells thrive. The findings could explain why colorectal cancer is being seen in younger people growing up at a time when higher-fat diets are common. Learn more: https://www.salk.edu/evans201902
Views: 827 Salk Institute
The ancient Egyptians swore by the life-extending benefits of mushrooms, and many modern scientists are beginning to feel the same way. The ancient Egyptians swore by the life-extending benefits of mushrooms, and many modern scientists are beginning to feel the same way. Recently, several studies have shown that the fungus has great potential in the arena of fighting cancer. Among those that have been specifically studied are white button, maitaki, reishi, and shiitake. Their benefits vary from inhibiting cell growth to actually shrinking the size of tumors. Both the white button and maitaki varieties show promise in treating breast cancer. Researchers working for City of Hope discovered that the common white button mushroom is capable of blocking a protein associated with breast tumors, resulting in a slowed growth rate. Scientists at Memorial Sloan-Kettering Cancer Center found that maitakis also showed evidence of combating the cancer cells by stimulating the body's immune system. Reishi mushrooms, on the other hand, are said to attack the antigens associated with tumors, resulting in the actual death of the malignant cells. Impressive results have also come from the studies of the shiitake. Experts at China's Harbin University of Science and Technology say they've isolated a compound in the mushroom that is capable of increasing survival rates and reducing the likelihood of the cancer returning.
Views: 712 GeoBeats News
Ovarian cancer is when abnormal cells in the ovary begin to grow and divide in an uncontrolled way, and eventually form a growth (tumour). There are different types of ovarian cancer. The type depends on the type of cell the cancer started in. Most cases of ovarian cancer are epithelial cancers. This means the cancer started in cells covering the ovary or fallopian tubes. Doctors now think that most epithelial cancers start in cells at the end of the fallopian tubes rather than the ovary. The risk of developing ovarian cancer increases as you get older. Most cases of epithelial ovarian cancer (the most common type) are in women older than 50. Find out more on ovarian cancer rates, symptoms, causes, treatments and how to reduce the risk. Watch the ten things you should know about ovarian cancer. Learn more about this type of cancer on our website: https://www.cancerresearchuk.org/about-cancer/ovarian-cancer
Views: 6697 Cancer Research UK
This video talks about cancer and it being one of the deadliest illnesses faced by man. https://en.wikipedia.org/wiki/Cancer Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread to other parts of the body. Possible signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss, and a change in bowel movements. While these symptoms may indicate cancer, they may have other causes. Over 100 types of cancers affect humans. Tobacco use is the cause of about 22% of cancer deaths. Another 10% are due to obesity, poor diet, lack of physical activity, and excessive drinking of alcohol. Other factors include certain infections, exposure to ionizing radiation and environmental pollutants. In the developing world, 15% of cancers are due to infections such as Helicobacter pylori, hepatitis B, hepatitis C, human papillomavirus infection, Epstein–Barr virus and human immunodeficiency virus. These factors act, at least partly, by changing the genes of a cell. Typically many genetic changes are required before cancer develops. Approximately 5–10% of cancers are due to inherited genetic defects from a person's parents. Cancer can be detected by certain signs and symptoms or screening tests. It is then typically further investigated by medical imaging and confirmed by biopsy. Many cancers can be prevented by not smoking, maintaining a healthy weight, not drinking too much alcohol, eating plenty of vegetables, fruits and whole grains, vaccination against certain infectious diseases, not eating too much processed and red meat, and avoiding too much sunlight exposure. Early detection through screening is useful for cervical and colorectal cancer. The benefits of screening in breast cancer are controversial. Cancer is often treated with some combination of radiation therapy, surgery, chemotherapy, and targeted therapy. Pain and symptom management are an important part of care. Palliative care is particularly important in people with advanced disease. The chance of survival depends on the type of cancer and extent of disease at the start of treatment. In children under 15 at diagnosis the five-year survival rate in the developed world is on average 80%. For cancer in the United States the average five-year survival rate is 66%. In 2015, about 90.5 million people had cancer. About 14.1 million new cases occur a year (not including skin cancer other than melanoma). It caused about 8.8 million deaths (15.7% of deaths). The most common types of cancer in males are lung cancer, prostate cancer, colorectal cancer and stomach cancer. In females, the most common types are breast cancer, colorectal cancer, lung cancer and cervical cancer. If skin cancer other than melanoma were included in total new cancers each year, it would account for around 40% of cases. In children, acute lymphoblastic leukemia and brain tumors are most common except in Africa where non-Hodgkin lymphoma occurs more often. In 2012, about 165,000 children under 15 years of age were diagnosed with cancer. The risk of cancer increases significantly with age and many cancers occur more commonly in developed countries. Rates are increasing as more people live to an old age and as lifestyle changes occur in the developing world. The financial costs of cancer were estimated at $1.16 trillion USD per year as of 2010.
Views: 5 Old Movies Reborn
Altogen Labs http://altogenlabs.com provides xenograft services http://altogenlabs.com/xenograft-models/pancreatic-xenograft-models/aspc-1-xenograft-model/. The AsPC-1 epithelial cell line is derived from pancreatic tissue of a 62-year-old Caucasian female patient with metastatic pancreatic adenocarcinoma. The AsPC-1 cell line is commonly employed for studying human infections related to the pancreas and is a powerful tool for pancreatic cancer research. The AsPC-1 human pancreas cell line is used to create the CDX (Cell Line Derived Xenograft) AsPC-1 xenograft mouse model that is utilized in preclinical research to study new therapeutic compounds targeting pancreatic cancer cells. Preclinical studies of pancreatic cancer can help researchers to investigate its correlation with immune response and find new therapies for patients with this disease. Xenografting is the transplantation of tissue from one species into another. Xenografting has been established as benchmark studies in pre-clinical cancer research. Typically, immunodeficient mice serve as hosts for a wide variety of human tumors, effectively serving as models for human subjects. Xenografting is a complete and accurate study of tumor growth and the activity of drug administration. -AsPC-1 Xenograft Study Data Endpoints Estimated tumor volume (L x W2 /2) Mean/median time to specified tumor volume Survival time to specified tumor volume Tumor doubling time Tumor growth inhibition (TGI) Tumor growth delay (TGD) Increased life span (ILS) Tumor cell kill rate -AsPC-1 Xenograft Model Advantages of Xenografting Develop new therapeutic agents quickly, efficiently and cost-effectively Evaluate the efficacy and toxicity of potential therapeutic agents Evaluate target compound activity using in vivo system (human cells) Predict cytotoxicity of cancer drugs -AsPC-1 Xenograft Model Basic Xenograft Study Xenograft studies can be designed to: Identify lead compounds Optimize dose schedules Identify combination strategies -AsPC-1 Xenograft Model Routes of drug administration: Intratumoral Intramuscular Oral gavage Intravenous Intratracheal Subcutaneous Intraperitoneal Continuous infusion Intranasal Using cutting-edge micro-injection techniques -AsPC-1 Xenograft Model Following options are available for the AsPC-1 xenograft model: AsPC-1 Tumor Growth Delay (TGD; latency) AsPC-1 Tumor Growth Inhibition (TGI) Dosing frequency and duration of dose administration AsPC-1 tumor immunohistochemistry Alternative cell engraftment sites (orthotopic transplantation, tail vein injection and left ventricular injection for metastasis studies, injection into the mammary fat pad, intraperitoneal injection) Blood chemistry analysis Toxicity and survival (optional: performing a broad health observation program) Gross necropsies and histopathology Positive control group employing cyclophosphamide, at a dosage of 50 mg/kg administered by intramuscular injection to the control group daily for the study duration Lipid distribution and metabolic assays Imaging studies: Fluorescence-based whole body imaging, MRI -AsPC-1 Xenograft Model Altogen Labs’ team of scientists carries extensive experience in Xenograft model research. Altogen Labs is compliant as a Good Laboratory Practices (GLP) environment, which is required by the FDA for pre-clinical research. Our Altogen Labs’ Xenograft services are extensive, rigorous, and flexible. Contact us to discuss Xenograft model details, timeline estimates, and price quotes! Connect to Altogen Labs: LinkedIn - https://www.linkedin.com/company/altogen-labs/ Twitter - https://twitter.com/altogen?lang=en Facebook - https://www.facebook.com/Altogen.CRO/
Views: 4105 Altogen Labs
In an article recently published in the Journal of the Royal Society Interface, Cambridge researchers have reported on measurements of biomechanical noise associated with the dynamic mechanical behaviour of adherent cells on a surface under normal growth conditions and when subjected to increasing levels of environmental stress. See more at: http://www.eng.cam.ac.uk/news/cambridge-researchers-quantify-biomechanical-noise-cancer-cells
10 Warning Signs of Cervical Cancer You Should Not Ignore Cervical cancer is one of the most common cancers in women worldwide. It occurs in the cells of the cervix, the lower part of the uterus that connects to the vagina. Almost all cases of cervical cancer are caused by a virus called human papillomavirus (HPV). Women of all ages are at risk of developing this cancer after they begin having sexual intercourse. Risk factors include unsafe sex, multiple sex partners, being overweight, use of oral contraceptives, genetics, smoking, poor immunity, multiple pregnancies and first pregnancy at a young age. One of the scariest things about this cancer is that it does not show any symptoms in its early stages. After the disease has spread to the bladder, liver, intestines or lungs, the symptoms are more prominent. Top 10 warning signs of cervical cancer you should not ignore. 1. Abnormal Vaginal Bleeding 2. Unusual Vaginal Discharge 3. Pain during Intercourse 4. Pelvic Pain 5. Discomfort while Urinating 6. Heavier and Longer Menstrual Periods 7. Loss of Bladder Control 8. Unexplained Weight Loss 9. Constant Fatigue 10. Leg Pain Thank you for watching ! If you like the video, give it a thumbs up and share it with your friends ! If you want more recipes and tips, subscribe to the channel ! Photos Licensed Under CC Resources: http://www.cancer.org/cancer/cervicalcancer/detailedguide/cervical-cancer-key-statistics -~-~~-~~~-~~-~- Please watch: "Rubbing Fingernails Together Stimulates Hair Growth and Reverses Graying: Reality or Myth" https://www.youtube.com/watch?v=M-snHGQ_xIM -~-~~-~~~-~~-~- #CervicalCancer #SignsofCervicalCancer
Views: 10856317 Natural Health Forever
Dr Eric Werner is the founder of Cellnomica, Inc., and the Oxford Advanced Research Foundation. He is in the Department of Physiology, Anatomy and Genetics, Department of Computer Science, Balliol Graduate Centre, University of Oxford. http://ericwerner.com/ ----------------------------------- The standard theory of cancer is that cancer results from uncontrolled growth, due to mutations in genes (Hanahan and Weinberg, 2000). Previous mathematical models accept this paradigm. In contrast I present a new paradigm of how cancer works based not on genes but developmental networks that control both normal cells and cancer cells (Werner, 2011b). This shift in understanding of how cancer works leads to a classification of all possible cancers based on their developmental control networks. It is a kind of periodic table of cancers that suggests fundamentally new research approaches to diagnosing, treating and curing cancers. The various cancer types have been modelled and simulated. In the talk I will describe the networks behind cancer stem cells. I will describe some interesting mathematical properties of stem cell networks that relate their ideal growth rates to the figurative numbers and Pascal's Triangle. Additionally, when cancer has spread the types of metastases that form depend on the kind of cancer network that generates the original tumour. There is a hierarchy of cancer networks with a corresponding hierarchy of metastases going from relatively harmless to increasingly dangerous tumours. I will also show why some cancers, like brain tumours, grow very slowly and then can suddenly become explosive. Cell signalling cancer networks similar to those underlying some bone cancers will also be described. This revolutionary new paradigm is related to the recent quest to understand the hidden code or "dark matter" the non-coding genome that makes up some 95% of all DNA in humans. References: Hanahan, D. and Weinberg, R.A., 2000. The hallmarks of cancer, Cell. 100, 57-70. Werner, E., 2011b. Cancer Networks: A general theoretical and computational framework for understanding cancer, arXiv:1110.5865v1 [q-bio.MN]. http://arxiv.org/abs/1110.5865. Copyright to the talk, slides and animations remains with Dr Werner. Oxford University Scientific Society website: http://users.ox.ac.uk/~science/ OUSS Facebook: http://www.facebook.com/OUSciSoc
Views: 2153 Oxford University Scientific Society
Scientists have been carrying out what seems to be a never-ending search to find newer and better ways for cancer treatment. Now, they have apparently found one of the most aggressive methods to tackle cancer cells: which is EXPLODING them! Scientists in Sweden claim they have discovered a new substance that can fight cancer through "an entirely new mechanism". The researchers say the compound can literally explode tumor cells belonging to the most aggressive form of brain cancer. They say they were able to reverse the growth of brain tumors in mice by giving them the substance that can be taken in tablet form. Scientists believe the mechanism has the potential to be applied to other types of cancers. The discovery was made after screening the effects of 1-thousabd different types of molecules on tumor cells.
Views: 777 PressTV
Exercise is supposed to be good for us， but there′s a new study out showing it could be harmful to people who have cancer. Korean researchers have discovered... a chemical compound that′s created during exercise that could potentially speed up the growth of cancer cells. Park Se－young reports. The body uses a lot of oxygen when you exercise， which is why you end up breathing heavily afterwards. This action isn′t always enough to supply the body with the oxygen it needs， so the body produces lactate， which acts as an energy source during exercise. But now， Korean researchers have discovered that a protein called NDRG3， which sends a signal to accelerate the growth of cancer cells， is also boosted by lactate. NDRG3 is present in all cells， and it promotes cell growth and the creation of blood vessels. A body with plenty of oxygen can break the protein down. Without enough oxygen， however， the protein combines with the lactate build－up，... speeding up cancer cell growth. The team′s experiments with mice showed that liver cancer cells in animals with NDRG3 grew at more than twice the rate as those in which the protein was suppressed. ″We′ve come to a deeper understanding of normal human bodily activity by studying the molecular basis for lactate－induced signaling. We can use the finding to develop therapies for disorders related to oxygen deficiency.″ Previous studies have shown the influence of lactate on tumor growth， but they weren′t able to explain how it happens and what role lactate plays in the process. Meanwhile， the team says cancer patients can′t forgo exercise completely， but should design their workouts in consultation with a physician. The discovery was published in the U.S. journal ″Cell″ in April. Park Se－young， Arirang News.
Views: 350 ARIRANG NEWS
Treatment may be needed if a lipoma is painful or growing quickly 23 jun 2016 this rapid growth does not automatically mean the phyllodes tumor malignant; Benign tumors can grow quickly, too. Though there are benign tumors, some can grow rapidly and really bother your dog. Googleusercontent search. So to develop a mass that is likely be problematic (say, about 5 you may relieved when your doctor tells tumor benign. Cancer cells grow in the same manner. It does not invade nearby tissue or spread to other parts of the body way fibromas (or fibroids) are tumors fibrous connective that can grow in any organ. However, unlike the cells in benign tumors, cancerous can invade nearby tissue and spread to other parts of body growth rates malignant tumors also differ; Benign generally grow more slowly than. Benign brain tumour nhs choicesdog lumps bumps tumors and growths the spruce. Benign brain tumor symptoms, signs & types medicinenet. Benign tumors causes, symptoms & diagnosis healthline benign healthline health url? Q webcache. Benign lung tumors causes, types, & more what are benign malignant tumors? Cancer sharecare. How fast does cancer grow? Dr. Aug 2016 in the case of tumors, dead cells remain and form a growth known as tumor. Although benign tumors generally grow slowly, cases of fast growing have also been documented 28 oct 2014 usually faster than tumours; Spread into and damage the cancer cells divide to create more will eventually unlike tumors, a non cancerous tumor is unable spread throughout body. However, undifferentiated benign tumors and differentiated malignant can occur. Benign tumors causes, symptoms & diagnosis healthline. Benign tumors grow as well defined masses that push normal cells out of the unlike malignant tumor cells, in benign do not metastasize 3 may 2017 does your dog have a tumor, lump, growth, or cyst? Learn about histiocytomas are red bumps can appear quickly on dog's skin. They do not spread to other parts of the body and are seldom a threat life. Are not cancerous, so will spread to other parts of the body; Grow slowly, benign tumors tend grow, but do invade beyond its borders and they can quickly surrounding tissue often have edges that are 10 dec 2015 a tumor does mean cancer be (not cancerous), pre malignant (pre or (cancerous). Benign tumors types, causes, and treatments webmd. Benign tumors can often be removed by surgery, and they are not likely to return the benign tumor usually grows at a relatively slow pace may stop growing malignant fast growing, fatal that invades surrounding 11 apr 2016 get facts on types of brain (glioma, astrocytoma, meningioma), their causes, symptoms (headache, memory problems), information about (non cancerous) tumours, including tumour, tumours graded from one four according how grow spread, but sometimes do back or become cancerous these cells continue faster than tissue, resulting in. Malignant cells do not have chemical adhesion molecules to anchor them the original growth i
Views: 612 Don't Question Me
Circulating Tumor Cells during Tumor Dormancy Tumor growth is the common denominator of cancer epidemiological functions. I shall show a simple way how to derive tumor growth from cancer statistics. Cumulative tumor recurrence levels off. As tumor growth slows down it becomes more and more dormant. Tumor growth slows down since host resistance rises. Leveling off of recurrence indicates: 1. Tumor growth declines 2. Host resistance rises 3. Probability of tumor dormancy rises All tissues are composed of Tissue Proliferative Units (TPU) and display the same cell kinetic structure: A two compartment cell renewal system with a feedback from Q to P. As tumor grows it maintains two compartments. I discuss publications about circulating tumor cells in cancer. Maturation arrest in CTCs 1. Rising cell size 2. Rising Nuclear to Cytoplasm ratio 3. Rising frequency of aneusomy (aneuploidy) 4. Rising frequency of gene mutations I regard tumor as an organ for producing fusion proteins. Since it sheds cells, it is a holocrine gland. CTCs carry fusion proteins to organs which need them. DNA molecules are messages exchanged between dynamic genomes. They are the third messaging system of the organism (after CNS and hormones)
Views: 791 Gershom Zajicek M.D,
Altogen Labs http://altogenlabs.com provides xenograft services http://altogenlabs.com/xenograft-models/ovarian-cancer-xenograft/sk-ov-3-xenograft-model/. The SK-OV-3 tumorigenic epithelial cell line was isolated in 1973 from the ovarian tissue of a 64-year-old Caucasian female patient with adenocarcinoma and is resistant to tumor necrosis and several other cytotoxic drugs, including Adriamycin, cis-platinum, and diphtheria toxin. Furthermore, this cell line is hypodiploid and is a suitable transfection host for ovarian cancer research. The SKOV-3 xenograft mouse model is created using human ovarian cells that are resistant both to tumor necrosis factor and to several cytotoxic drugs and is a helpful tool in ovarian cancer research. Preclinical studies of ovarian cancer can help researchers to investigate its correlation with immune response and find new therapies for patients with this disease. Xenografting is the transplantation of tissue from one species into another. Xenografting has been established as benchmark studies in pre-clinical cancer research. Typically, immunodeficient mice serve as hosts for a wide variety of human tumors, effectively serving as models for human subjects. Xenografting is a complete and accurate study of tumor growth and the activity of drug administration. -SK-OV-3 Xenograft Study Data Endpoints Estimated tumor volume (L x W2 /2) Mean/median time to specified tumor volume Survival time to specified tumor volume Tumor doubling time Tumor growth inhibition (TGI) Tumor growth delay (TGD) Increased life span (ILS) Tumor cell kill rate -SK-OV-3 Xenograft Model Advantages of Xenografting Develop new therapeutic agents quickly, efficiently and cost-effectively Evaluate the efficacy and toxicity of potential therapeutic agents Evaluate target compound activity using in vivo system (human cells) Predict cytotoxicity of cancer drugs -SK-OV-3 Xenograft Model Basic Xenograft Study Xenograft studies can be designed to: Identify lead compounds Optimize dose schedules Identify combination strategies -SK-OV-3 Xenograft Model Routes of drug administration: Intratumoral Intramuscular Oral gavage Intravenous Intratracheal Subcutaneous Intraperitoneal Continuous infusion Intranasal Using cutting-edge micro-injection techniques -SK-OV-3 Xenograft Model Following options are available for the SK-OV-3 xenograft model: SK-OV-3 Tumor Growth Delay (TGD; latency) SK-OV-3 Tumor Growth Inhibition (TGI) Dosing frequency and duration of dose administration SK-OV-3 tumor immunohistochemistry Alternative cell engraftment sites (orthotopic transplantation, tail vein injection and left ventricular injection for metastasis studies, injection into the mammary fat pad, intraperitoneal injection) Blood chemistry analysis Toxicity and survival (optional: performing a broad health observation program) Gross necropsies and histopathology Positive control group employing cyclophosphamide, at a dosage of 50 mg/kg administered by intramuscular injection to the control group daily for the study duration Lipid distribution and metabolic assays Imaging studies: Fluorescence-based whole body imaging, MRI -SK-OV-3 Xenograft Model Altogen Labs’ team of scientists carries extensive experience in Xenograft model research. Altogen Labs is compliant as a Good Laboratory Practices (GLP) environment, which is required by the FDA for pre-clinical research. Our Altogen Labs’ Xenograft services are extensive, rigorous, and flexible. Contact us to discuss Xenograft model details, timeline estimates, and price quotes! Connect to Altogen Labs: LinkedIn - https://www.linkedin.com/company/altogen-labs/ Twitter - https://twitter.com/altogen?lang=en Facebook - https://www.facebook.com/Altogen.CRO/
Views: 516 Altogen Labs
https://www.ibiology.org/genetics-and-gene-regulation/telomerase/#part-2 Telomerase, a specialized ribonucleprotein reverse transcriptase, is important for long-term eukaryotic cell proliferation and genomic stability, because it replenishes the DNA at telomeres. Thus depending on cell type telomerase partially or completely (depending on cell type) counteracts the progressive shortening of telomeres that otherwise occurs. Telomerase is highly active in many human malignancies, and a potential target for anti-cancer approaches. Furthermore, recent collaborative studies have shown the relationship between accelerated telomere shortening and life stress and that low telomerase levels are associated with six prominent risk factors for cardiovascular disease.
Views: 36312 iBiology
Tumor Dormancy Introduction Tumor growth is the common denominator of epidemiological statistics of cancer. First I show how to derive tumor growth from epidemiological observations. Then I show that Gompertz function is adequate to describe tumor growth. If tumor inception is known we may estimate its mean growth velocity. Tumor burden at diagnosis = 1 Time between inception and diagnosis = t[1 ]- t Velocity = 1 / (t[1 ]- t) Here are two examples where tumor inception is known: 1. Cancer recurrence 2. Interval cancer. Cancer is an interaction between organism and tumor. In other presentations I show that organism controls both rates. This capability I call host resistance. Tapering off of the curve indicates that host resistance rises . Tumor growth is a common denominator of epidemiological functions which may be derived from the Gompertz function. Stated otherwise. Gompertz function is a common denominator of clinical and epidemiological cancer manifestations. Leveling off of the cumulative recurrence indicate that with time tumor grows slower and host resistance rises. The longer she lives the slower tumor growth. Cancer is an incurable chronic disease which extended periods of dormancy. All these women carried tumors whose growth rates decline. Which is manifested clinically as tumor dormancy.
Views: 472 Gershom Zajicek M.D,
Cancer ancer /ˈkænsər/ ( listen), known medically as a malignant neoplasm, is a broad group of various diseases, all involving unregulated cell growth. In cancer, cells divide and grow uncontrollably, forming malignant tumors, and invade nearby parts of the body. The cancer may also spread to more distant parts of the body through the lymphatic system or bloodstream. Not all tumors are cancerous. Benign tumors do not grow uncontrollably, do not invade neighboring tissues, and do not spread throughout the body. Determining what causes cancer is complex. Many things are known to increase the risk of cancer, including tobacco use, certain infections, radiation, lack of physical activity, poor diet and obesity, and environmental pollutants. These can directly damage genes or combine with existing genetic faults within cells to cause the disease. Approximately five to ten percent of cancers are entirely hereditary. Cancer can be detected in a number of ways, including the presence of certain signs and symptoms, screening tests, or medical imaging. Once a possible cancer is detected it is diagnosed by microscopic examination of a tissue sample. Cancer is usually treated with chemotherapy, radiation therapy and surgery. The chances of surviving the disease vary greatly by the type and location of the cancer and the extent of disease at the start of treatment. While cancer can affect people of all ages, and a few types of cancer are more common in children, the risk of developing cancer generally increases with age. In 2007, cancer caused about 13% of all human deaths worldwide (7.9 million). Rates are rising as more people live to an old age and as mass lifestyle changes occur in the developing world.
Views: 231 definition2012